Notochord development

Across TCGA cell cohorts, RNA activity of the Notochord development pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJB5, RIC1, and KLHL5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAJB5 grouped by Notochord development-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	DNAJB5 →	-0.828	-1.031	.005	.001	3	4
BLOOD_Leukemia	RIC1 →	-1.220	-0.936	.008	.004	2	5
STOMACH	KLHL5 →	-2.610	-0.241	<.001	.001	3	3
STOMACH	ZYG11B →	-0.605	-0.271	<.001	<.001	3	3
STOMACH	PRICKLE2 →	-1.688	-0.399	.001	.001	3	3
LIVER	APOL3 →	-1.640	-0.803	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAJB5 by Notochord development activity — KIDNEY

Explore this box plot interactively →