Hindbrain development

Across TCGA patient cohorts, RNA activity of the Hindbrain development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCAN, MAP1A_S667, and PFN2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hindbrain development activity versus VCAN in BRCA (Pearson r = -0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VCAN →	+0.956	+0.024	<.001	<.001	3	7
HNSC	MAP1A_S667 →	+0.653	+0.036	<.001	.005	3	7
HNSC	PFN2 →	+0.596	+0.049	<.001	.001	3	6
HNSC	VCAN_S2116 →	+1.171	+0.044	<.001	.001	2	7
PDAC	CUL3_S737 →	+0.652	+0.023	.006	.001	3	6
HNSC	CHST14 →	+0.417	+0.043	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030902 vs VCAN — BRCA

Explore this scatter interactively →