Hindbrain development

Across TCGA patient cohorts, RNA activity of the Hindbrain development pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTA2, CALD1, and PDGFRA, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hindbrain development activity versus ACTA2 in OV (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ACTA2 →	+1.752	+0.154	<.001	<.001	3	3
CCRCC	CALD1 →	+0.530	+1.215	.007	<.001	3	3
OV	PDGFRA →	+1.502	+0.224	<.001	<.001	3	3
OV	LMOD1 →	+1.195	+0.189	<.001	<.001	3	3
CCRCC	ZNF34 →	+0.313	+0.795	<.001	.002	3	3
CCRCC	SMARCAL1-AS1 →	-0.172	-0.966	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030902 vs ACTA2 — OV

Explore this scatter interactively →