Hindbrain development

Across TCGA cell cohorts, RNA activity of the Hindbrain development pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFI16, FOXL2, and STC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IFI16 grouped by Hindbrain development-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	IFI16 →	-3.106	-0.879	.007	.007	3	6
OESOPHAGUS	FOXL2 →	-1.104	-0.165	.004	.007	3	5
SKIN	STC2 →	-1.993	-0.397	.003	.009	3	5
SKIN	LTBP2 →	-1.017	-0.408	.006	.007	3	5
BREAST	LARP6 →	-1.259	-0.375	.008	.007	3	5
OVARY	MAP1B →	-2.416	-0.257	.003	.009	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IFI16 by Hindbrain development activity — LIVER

Explore this box plot interactively →