Midbrain development

Across TCGA patient cohorts, RNA activity of the Midbrain development pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLPX, GULP1, and ANGPTL2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Midbrain development activity versus CLPX in LUAD (Pearson r = -0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CLPX →	-0.193	-0.021	.001	.004	3	7
LSCC	GULP1 →	+0.368	+0.040	.002	<.001	3	7
CCRCC	ANGPTL2 →	+0.584	+0.026	.001	.002	3	7
BRCA	DPYSL3 →	+0.418	+0.032	<.001	<.001	3	7
CCRCC	HTRA1 →	+0.787	+0.037	<.001	<.001	3	7
PDAC	DIP2C →	+0.216	+0.020	.007	.008	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030901 vs CLPX — LUAD

Explore this scatter interactively →