Midbrain development

Across TCGA patient cohorts, RNA activity of the Midbrain development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKCH, NQO2-AS1, and PPT2-EGFL8, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Midbrain development activity versus PRKCH in UCEC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRKCH →	+0.544	+0.135	.002	.008	3	7
BRCA	NQO2-AS1 →	-0.175	-0.114	<.001	.002	3	4
BRCA	PPT2-EGFL8 →	-0.124	-0.130	.002	.001	3	4
LUAD	GATA2 →	+0.477	+0.134	.007	<.001	3	3
CCRCC	DNTTIP1 →	-0.613	-0.069	.005	.002	3	3
CCRCC	PTGDS →	+0.364	+0.062	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030901 vs PRKCH — UCEC

Explore this scatter interactively →