Midbrain development

Across TCGA patient cohorts, RNA activity of the Midbrain development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NUDT21, ZNF638_S552, and SELENOP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Midbrain development activity versus NUDT21 in OV (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NUDT21 →	-0.269	-0.122	<.001	.001	3	4
COAD	ZNF638_S552 →	-0.463	-0.119	.001	.002	3	3
CCRCC	SELENOP →	+0.467	+0.085	.001	<.001	3	3
CCRCC	TNXB →	+0.603	+0.069	<.001	.003	3	3
OV	WDFY3_S3339 →	+0.667	+0.124	.006	.002	3	3
BRCA	CHERP →	-0.189	-0.100	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030901 vs NUDT21 — OV

Explore this scatter interactively →