Midbrain development

Across TCGA cell cohorts, RNA activity of the Midbrain development pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACSL1, TMEM63B, and ETHE1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACSL1 grouped by Midbrain development-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ACSL1 →	+1.785	+0.250	<.001	<.001	3	4
OVARY	TMEM63B →	+0.655	+0.222	.003	<.001	3	4
LARGE_INTESTINE	ETHE1 →	+1.184	+0.147	.003	.008	3	4
LARGE_INTESTINE	TNFRSF10B →	+0.909	+0.158	.002	.002	3	4
LIVER	PFDN2 →	-0.736	-0.246	.001	.008	2	4
LIVER	RNF152 →	-0.615	-0.242	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACSL1 by Midbrain development activity — KIDNEY

Explore this box plot interactively →