Midbrain development

Across TCGA cell cohorts, RNA activity of the Midbrain development pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHDC8B, C22orf39, and NUDT19, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Midbrain development activity versus KLHDC8B in OESOPHAGUS (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	KLHDC8B →	+2.277	+0.292	<.001	<.001	3	5
LUNG_SCLC	C22orf39 →	+1.155	+0.173	.002	<.001	3	5
BLOOD_Leukemia	NUDT19 →	+1.450	+0.154	.001	<.001	3	4
BREAST	OSGIN1 →	+2.061	+0.309	<.001	<.001	3	4
OESOPHAGUS	PPP1R9B →	+1.272	+0.266	<.001	<.001	3	4
OESOPHAGUS	KLHL2 →	+1.094	+0.254	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030901 vs KLHDC8B — OESOPHAGUS

Explore this scatter interactively →