Positive regulation of B cell proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of B cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SP140, NFATC2, and LAX1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of B cell proliferation activity versus SP140 in CCRCC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SP140 →	+0.832	+0.885	<.001	.001	3	9
GBM	NFATC2 →	+0.710	+0.742	<.001	.001	3	8
HNSC	LAX1 →	+1.519	+1.251	<.001	<.001	3	8
HNSC	CD4 →	+0.819	+1.152	<.001	<.001	3	7
HNSC	NCKAP1L →	+1.148	+1.305	<.001	<.001	3	7
CCRCC	WDFY4 →	+0.674	+0.708	<.001	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030890 vs SP140 — CCRCC

Explore this scatter interactively →