Positive regulation of B cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of B cell proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TFRC, FYN, and H2AX, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TFRC grouped by Positive regulation of B cell proliferation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TFRC →	-0.416	-0.150	<.001	.004	3	6
BLOOD_Myeloma	FYN →	-0.248	-0.246	.006	.009	3	5
SKIN	H2AX →	+0.127	+0.383	<.001	<.001	3	5
LUNG_NSCLC_LUAD	RPS19 →	-0.211	-0.221	<.001	.002	3	5
LUNG_NSCLC_LUAD	CCT5 →	+0.210	+0.196	.001	.007	3	5
LARGE_INTESTINE	TIRAP →	-0.329	-0.321	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TFRC by Positive regulation of B cell proliferation activity — BREAST

Explore this box plot interactively →