Positive regulation of B cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of B cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXOSC7, ZNF665, and RPN2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EXOSC7 grouped by Positive regulation of B cell proliferation-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	EXOSC7 →	-0.818	-0.385	<.001	.008	3	3
OVARY	ZNF665 →	+1.033	+0.250	.002	.001	2	4
OESOPHAGUS	RPN2 →	+0.853	+0.327	.002	.002	3	3
OESOPHAGUS	BMP2K →	+1.013	+0.312	.005	.005	3	3
OESOPHAGUS	TCN2 →	+1.672	+0.271	<.001	.002	3	3
LUNG_SCLC	DDIT4 →	-2.095	-0.265	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EXOSC7 by Positive regulation of B cell proliferation activity — PANCREAS

Explore this box plot interactively →