Negative regulation of B cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of B cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN2A, CDKN2B, and TNFRSF21, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of B cell proliferation activity versus CDKN2A in LIVER (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CDKN2A →	+4.097	+0.254	.009	.005	3	16
PANCREAS	CDKN2B →	+2.729	+0.164	<.001	<.001	3	12
BREAST	TNFRSF21 →	+2.308	+0.353	<.001	.003	3	12
BREAST	JRKL →	+0.807	+0.139	.003	.003	3	9
CNS	NPAT →	+0.603	+0.157	<.001	<.001	2	9
URINARY_TRACT	CCDC9B →	+2.948	+0.226	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030889 vs CDKN2A — LIVER

Explore this scatter interactively →