Negative regulation of B cell proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of B cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PFDN1, RAD1, and CEP104, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of B cell proliferation activity versus PFDN1 in BLOOD_Leukemia (Pearson r = 0.95).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PFDN1 →	+0.736	+1.979	.004	<.001	3	1
BLOOD_Leukemia	RAD1 →	+1.043	+1.990	.006	<.001	3	1
BLOOD_Leukemia	CEP104 →	-0.986	-1.924	.009	<.001	3	1
BLOOD_Leukemia	USP35 →	+0.513	+1.877	.002	<.001	3	1
BLOOD_Leukemia	ELOVL3 →	+3.446	+1.990	<.001	<.001	3	1
BLOOD_Leukemia	DCTD →	-0.583	-1.979	.008	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030889 vs PFDN1 — BLOOD_Leukemia

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