Regulation of B cell proliferation

Across TCGA patient cohorts, RNA activity of the Regulation of B cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, SEPTIN1, and STK10_S514, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of B cell proliferation activity versus RCSD1 in GBM (Pearson r = 0.75).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RCSD1 →	+0.630	+0.075	<.001	<.001	3	10
BRCA	SEPTIN1 →	+1.030	+0.052	<.001	<.001	3	10
LSCC	STK10_S514 →	+0.892	+0.081	<.001	<.001	3	10
GBM	STX11 →	+0.592	+0.066	<.001	<.001	3	10
GBM	TBC1D2B →	+0.434	+0.080	<.001	<.001	3	10
GBM	WAS →	+0.733	+0.087	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030888 vs RCSD1 — GBM

Explore this scatter interactively →