Regulation of B cell proliferation

Across TCGA patient cohorts, RNA activity of the Regulation of B cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM78A, NCKAP1L, and WDFY4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of B cell proliferation activity versus FAM78A in OV (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FAM78A →	+0.655	+0.749	.008	.006	3	8
HNSC	NCKAP1L →	+0.882	+1.271	<.001	<.001	3	8
LSCC	WDFY4 →	+0.900	+0.593	<.001	<.001	3	8
LSCC	FGD2 →	+0.867	+0.607	<.001	<.001	3	8
OV	GAB3 →	+0.732	+0.734	<.001	.004	3	8
LSCC	ZC3H12D →	+0.714	+0.605	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030888 vs FAM78A — OV

Explore this scatter interactively →