Regulation of myeloid dendritic cell activation

Across TCGA patient cohorts, RNA activity of the Regulation of myeloid dendritic cell activation pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD3D, SLA2, and UBASH3A, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of myeloid dendritic cell activation activity versus CD3D in SCLC (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	CD3D →	+2.925	+1.485	<.001	<.001	3	32
SKCM	SLA2 →	+1.713	+0.086	<.001	<.001	3	31
SKCM	UBASH3A →	+1.448	+0.087	<.001	<.001	3	31
SCLC	CD3G →	+2.369	+1.838	<.001	<.001	3	31
SCLC	SH2D1A →	+2.443	+1.160	<.001	<.001	2	32
SCLC	GZMH →	+2.667	+1.590	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030885 vs CD3D — SCLC

Explore this scatter interactively →