Regulation of myeloid dendritic cell activation

Across TCGA patient cohorts, RNA activity of the Regulation of myeloid dendritic cell activation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF831, GRAP2, and ITK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of myeloid dendritic cell activation activity versus ZNF831 in CCRCC (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ZNF831 →	+0.888	+0.963	<.001	<.001	3	6
BRCA	GRAP2 →	+0.646	+0.383	<.001	<.001	3	6
BRCA	ITK →	+0.836	+0.409	<.001	<.001	3	6
BRCA	CD48 →	+0.750	+0.379	<.001	<.001	3	6
BRCA	CCR7 →	+1.434	+0.727	<.001	<.001	3	6
CCRCC	TESPA1 →	+0.909	+0.954	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030885 vs ZNF831 — CCRCC

Explore this scatter interactively →