Thyroid gland development

Across TCGA patient cohorts, RNA activity of the Thyroid gland development pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAP1GAP, GPAT3, and ZBTB7C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thyroid gland development activity versus RAP1GAP in LUAD (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RAP1GAP →	+1.042	+0.220	<.001	<.001	3	5
BRCA	GPAT3 →	+0.656	+0.200	<.001	<.001	3	4
HNSC	ZBTB7C →	+1.127	+0.428	<.001	<.001	3	4
PDAC	TRIM4 →	+0.320	+0.425	.008	.003	3	4
LSCC	THSD7B →	+0.751	+0.256	.001	.008	2	5
LUAD	CRYM →	+1.118	+0.169	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030878 vs RAP1GAP — LUAD

Explore this scatter interactively →