Thyroid gland development

Across TCGA cell cohorts, RNA activity of the Thyroid gland development pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGF10, MAP2K1, and LOXHD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FGF10 grouped by Thyroid gland development-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FGF10 →	-0.211	-0.704	<.001	.006	3	5
SKIN	MAP2K1 →	-0.194	-0.525	<.001	.001	3	5
OESOPHAGUS	LOXHD1 →	+0.174	+0.372	.006	.005	2	5
BLOOD_Myeloma	NSF →	+0.573	+2.221	.002	<.001	3	4
LARGE_INTESTINE	PCDH17 →	+0.180	+1.020	.001	.004	3	4
LARGE_INTESTINE	MIEN1 →	+0.163	+0.736	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FGF10 by Thyroid gland development activity — BLOOD_Leukemia

Explore this box plot interactively →