Thyroid gland development

Across TCGA cell cohorts, RNA activity of the Thyroid gland development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H3C15, SLC27A1, and POLR3K, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, H3C15 grouped by Thyroid gland development-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	H3C15 →	+0.653	+0.840	.001	<.001	2	5
BLOOD_Myeloma	SLC27A1 →	+0.522	+1.666	.009	<.001	3	4
OESOPHAGUS	POLR3K →	+1.217	+0.965	<.001	.001	3	4
SOFT_TISSUE	SLC6A6 →	-1.385	-0.881	.001	.008	3	4
BLOOD_Lymphoma	EFHC1 →	-1.583	-1.318	.008	.007	3	4
OVARY	DZIP3 →	+1.138	+0.910	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

H3C15 by Thyroid gland development activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →