Polarized epithelial cell differentiation

Across TCGA patient cohorts, RNA activity of the Polarized epithelial cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GIMAP8, CYBB, and FCER1G, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polarized epithelial cell differentiation activity versus GIMAP8 in LUAD (Pearson r = -0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GIMAP8 →	-0.350	-0.060	<.001	<.001	3	8
LUAD	CYBB →	-0.593	-0.066	<.001	<.001	3	7
UCEC	FCER1G →	-0.656	-0.043	.007	.005	3	7
HNSC	PTPRC →	-0.492	-0.068	.001	<.001	3	7
COAD	ICAM3 →	-0.412	-0.032	<.001	.001	3	7
BRCA	THEMIS2 →	-0.398	-0.030	<.001	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030859 vs GIMAP8 — LUAD

Explore this scatter interactively →