Polarized epithelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Polarized epithelial cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OLIG1, TRAPPC3, and PSMD11, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OLIG1 grouped by Polarized epithelial cell differentiation-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OLIG1 →	-0.230	-0.212	.003	<.001	3	5
LUNG_NSCLC_LUAD	TRAPPC3 →	-0.469	-0.118	<.001	<.001	3	5
LUNG_NSCLC_LUSC	PSMD11 →	+0.470	+0.173	.006	.004	3	5
BONE	NDUFA12 →	-0.392	-0.148	.001	.004	2	6
SKIN	GPR85 →	-0.143	-0.075	<.001	<.001	3	4
LUNG_SCLC	NLK →	-0.182	-0.164	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OLIG1 by Polarized epithelial cell differentiation activity — URINARY_TRACT

Explore this box plot interactively →