Polarized epithelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Polarized epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAMK2N1, N6AMT1, and TBC1D31, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polarized epithelial cell differentiation activity versus CAMK2N1 in LUNG_SCLC (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CAMK2N1 →	-2.263	-0.167	.001	.002	3	5
LUNG_NSCLC_LUAD	N6AMT1 →	+0.695	+0.188	<.001	<.001	3	4
LUNG_SCLC	TBC1D31 →	+0.743	+0.183	.002	.001	3	4
LUNG_NSCLC_LUAD	ZNF709 →	+0.372	+0.184	.005	<.001	3	4
BLOOD_Lymphoma	AREG →	-1.283	-0.213	<.001	<.001	3	4
LARGE_INTESTINE	ZMYM3 →	+0.735	+0.188	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030859 vs CAMK2N1 — LUNG_SCLC

Explore this scatter interactively →