Positive regulation of epithelial cell differentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of epithelial cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SCEL_S68, TJP1, and CDC42EP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of epithelial cell differentiation activity versus SCEL_S68 in UCEC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SCEL_S68 →	+1.463	+0.054	<.001	<.001	3	5
LSCC	TJP1 →	+0.153	+0.025	.003	.007	3	5
PDAC	CDC42EP1 →	+0.390	+0.028	.002	.004	3	5
UCEC	SERPINB5 →	+1.221	+0.047	<.001	.001	3	5
HNSC	CENPC_S709 →	-0.374	-0.032	<.001	.001	3	5
OV	CDC42EP1_S121 →	+1.121	+0.025	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030858 vs SCEL_S68 — UCEC

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