Positive regulation of epithelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MZT2A, ALDH1A3, and RRP7A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MZT2A grouped by Positive regulation of epithelial cell differentiation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MZT2A →	-0.617	-0.217	.004	.007	3	5
BLOOD_Lymphoma	ALDH1A3 →	-0.807	-0.244	.002	.008	3	4
LUNG_SCLC	RRP7A →	-0.625	-0.214	.001	.008	3	4
LUNG_NSCLC_LUAD	SLC30A5 →	+0.404	+0.162	.004	.007	3	3
LUNG_NSCLC_LUAD	GTF2IRD1 →	+0.829	+0.233	<.001	<.001	3	3
SOFT_TISSUE	TCTA →	-0.810	-0.173	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MZT2A by Positive regulation of epithelial cell differentiation activity — CNS

Explore this box plot interactively →