Negative regulation of epithelial cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the MESO cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDGFRB, ADGRA2, and PDGFB, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of epithelial cell differentiation activity versus PDGFRB in MESO (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
MESO	PDGFRB →	+1.882	+0.048	<.001	<.001	3	33
LIHC	ADGRA2 →	+1.550	+0.050	<.001	<.001	3	33
CHOL	PDGFB →	+1.402	+0.070	<.001	<.001	3	32
TGCT	NID1 →	+1.819	+0.086	<.001	<.001	3	32
MESO	FMNL3 →	+1.053	+0.039	<.001	<.001	3	32
UCS	FBN1 →	+1.792	+0.084	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030857 vs PDGFRB — MESO

Explore this scatter interactively →