Negative regulation of epithelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM43, CD151, and EXT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM43 grouped by Negative regulation of epithelial cell differentiation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TMEM43 →	-0.935	-0.959	.002	<.001	3	5
LUNG_NSCLC_LUSC	CD151 →	-1.675	-1.809	.003	<.001	3	5
OVARY	EXT1 →	-1.455	-0.960	.004	.001	3	5
LUNG_SCLC	KBTBD6 →	+0.643	+1.252	.008	<.001	2	5
LUNG_SCLC	SAMD4A →	-2.468	-1.169	.008	.003	3	4
BLOOD_Leukemia	SF3B6 →	+0.471	+0.891	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM43 by Negative regulation of epithelial cell differentiation activity — BREAST

Explore this box plot interactively →