Negative regulation of epithelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPC2, PLAAT4, and CAV1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of epithelial cell differentiation activity versus NPC2 in LUNG_NSCLC_LUSC (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NPC2 →	+1.937	+0.444	.005	.003	3	7
BONE	PLAAT4 →	+2.829	+0.364	.001	<.001	3	6
LUNG_NSCLC_LUSC	CAV1 →	+5.812	+0.405	.008	.003	2	7
PANCREAS	F3 →	+5.119	+0.415	<.001	.002	3	6
PANCREAS	ANXA8 →	+3.432	+0.439	.005	.001	3	6
KIDNEY	NCEH1 →	+1.710	+0.346	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030857 vs NPC2 — LUNG_NSCLC_LUSC

Explore this scatter interactively →