Regulation of epithelial cell differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPARC, TIMP2, and FNDC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of epithelial cell differentiation activity versus SPARC in BRCA (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SPARC →	+0.972	+0.300	.002	.008	3	5
BRCA	TIMP2 →	+0.968	+0.394	<.001	.001	3	5
BRCA	FNDC1 →	+0.703	+0.216	.004	.006	3	5
PDAC	TIMP3 →	+0.769	+0.141	<.001	<.001	3	4
BRCA	SH3D19 →	+0.515	+0.310	.008	.008	3	4
PDAC	INHBA →	+0.674	+0.127	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030856 vs SPARC — BRCA

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