Regulation of epithelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of epithelial cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC16A3, TPR, and NUTM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC16A3 grouped by Regulation of epithelial cell differentiation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC16A3 →	-0.104	-0.159	<.001	.008	3	4
OVARY	TPR →	-0.167	-0.265	.002	<.001	3	4
BLOOD_Leukemia	NUTM1 →	+0.373	+0.235	.001	<.001	3	4
SKIN	LIFR →	+0.243	+0.208	<.001	.001	3	3
BLOOD_Leukemia	DNAJB9 →	+0.233	+0.217	.002	.009	2	4
STOMACH	PTK7 →	+0.289	+0.269	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC16A3 by Regulation of epithelial cell differentiation activity — SKIN

Explore this box plot interactively →