Regulation of epithelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPRY4, RFK, and SPECC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of epithelial cell differentiation activity versus SPRY4 in PANCREAS (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SPRY4 →	-1.904	-0.406	.007	.009	2	6
PANCREAS	RFK →	-1.201	-0.400	<.001	<.001	3	5
URINARY_TRACT	SPECC1 →	+1.602	+0.162	.003	.007	3	4
PANCREAS	SCEL →	+4.087	+0.478	.002	<.001	3	4
OESOPHAGUS	FGFBP1 →	+2.585	+0.223	.005	.001	3	4
LUNG_NSCLC_LUAD	HCAR2 →	+0.742	+0.239	.009	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030856 vs SPRY4 — PANCREAS

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