Positive regulation of granulocyte differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of granulocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASA4, AKAP6, and PLA2G6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RASA4 grouped by Positive regulation of granulocyte differentiation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RASA4 →	+1.367	+0.737	<.001	<.001	3	4
OVARY	AKAP6 →	+1.544	+0.409	.008	<.001	2	5
LARGE_INTESTINE	PLA2G6 →	+1.588	+1.090	<.001	<.001	3	4
KIDNEY	ANKRD13A →	-1.284	-1.267	<.001	.001	3	4
BONE	RAD50 →	-0.672	-0.328	.001	.008	3	4
OVARY	RASA4B →	+1.252	+0.787	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RASA4 by Positive regulation of granulocyte differentiation activity — OVARY

Explore this box plot interactively →