Positive regulation of granulocyte differentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of granulocyte differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AQP11, LNPEP, and TBCC, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AQP11 grouped by Positive regulation of granulocyte differentiation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	AQP11 →	+0.116	+1.787	.004	<.001	3	2
LARGE_INTESTINE	LNPEP →	+0.240	+1.558	.004	.002	3	2
LARGE_INTESTINE	TBCC →	-0.190	-1.874	.006	<.001	3	2
LARGE_INTESTINE	SERINC3 →	+0.335	+1.558	.002	.002	3	2
LARGE_INTESTINE	ETS2 →	+0.198	+1.781	<.001	<.001	3	2
LARGE_INTESTINE	ITIH3 →	+0.176	+1.919	.009	<.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AQP11 by Positive regulation of granulocyte differentiation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →