Negative regulation of granulocyte differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of granulocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRTAM, CD2, and LY9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of granulocyte differentiation activity versus CRTAM in CCRCC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CRTAM →	+0.712	+0.289	<.001	<.001	3	6
GBM	CD2 →	+1.253	+0.582	<.001	.001	3	6
HNSC	LY9 →	+0.471	+0.277	.001	.004	3	6
CCRCC	ICOS →	+1.014	+0.413	<.001	.007	3	6
GBM	RHOH →	+0.921	+0.763	<.001	<.001	3	6
HNSC	INPP5D →	+0.877	+0.510	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030853 vs CRTAM — CCRCC

Explore this scatter interactively →