Negative regulation of granulocyte differentiation

Across TCGA cell cohorts, RNA activity of the Negative regulation of granulocyte differentiation pathway is significantly associated with the drug response of multiple features, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are ZM447439, MIM1, and PLX-4720, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZM447439 grouped by Negative regulation of granulocyte differentiation-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZM447439 →	-0.759	-1.472	.028	.003	3	2
BLOOD_Lymphoma	MIM1 →	-0.410	-1.522	.028	<.001	2	3
PANCREAS	PLX-4720 →	+0.580	+1.273	<.001	.021	3	2
BLOOD_Lymphoma	RO-3306 →	-0.245	-1.311	.039	.004	2	2
BLOOD_Lymphoma	IAP_7638 →	+0.794	+1.522	.005	<.001	3	1
BLOOD_Lymphoma	MCT4_1422 →	+0.580	+1.444	.018	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZM447439 by Negative regulation of granulocyte differentiation activity — BLOOD_Lymphoma

Explore this box plot interactively →