Regulation of granulocyte differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of granulocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCF4, NLRC4, and BTK, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of granulocyte differentiation activity versus NCF4 in GBM (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NCF4 →	+0.788	+0.624	<.001	<.001	3	8
OV	NLRC4 →	+0.574	+0.631	.006	.006	3	8
UCEC	BTK →	+0.625	+0.468	.003	<.001	3	8
HNSC	GNGT2 →	+0.832	+0.626	.003	<.001	3	8
UCEC	AIF1 →	+1.115	+0.588	<.001	<.001	3	8
GBM	CCR5AS →	+0.865	+0.814	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030852 vs NCF4 — GBM

Explore this scatter interactively →