Regulation of granulocyte differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of granulocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLOD3, ARHGAP25, and DPP9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLOD3 grouped by Regulation of granulocyte differentiation-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PLOD3 →	-1.174	-0.647	.001	.001	3	4
OVARY	ARHGAP25 →	+0.804	+0.564	<.001	.007	3	4
LARGE_INTESTINE	DPP9 →	-0.515	-0.861	.005	.005	3	3
LARGE_INTESTINE	PCMTD1 →	+1.053	+0.778	<.001	.002	3	3
LARGE_INTESTINE	MZF1 →	+0.929	+0.826	.001	.006	3	3
BLOOD_Leukemia	PRPF19 →	+0.549	+0.690	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLOD3 by Regulation of granulocyte differentiation activity — BLOOD_Leukemia

Explore this box plot interactively →