Regulation of granulocyte differentiation

Across TCGA cell cohorts, RNA activity of the Regulation of granulocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLOD1, SNAI1, and MACO1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of granulocyte differentiation activity versus PLOD1 in LUNG_NSCLC_LUAD (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PLOD1 →	-1.082	-1.398	.005	<.001	3	4
SKIN	SNAI1 →	-2.159	-1.454	<.001	<.001	3	4
BLOOD_Lymphoma	MACO1 →	+0.780	+0.739	.003	.009	3	3
OVARY	IDH3B →	+1.686	+2.114	.001	<.001	3	3
BONE	EML6 →	+1.970	+1.781	.001	<.001	2	4
OVARY	HSD17B14 →	+2.010	+1.458	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030852 vs PLOD1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →