Granulocyte differentiation

Across TCGA patient cohorts, RNA activity of the Granulocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFSF13B, PIK3CG, and CD48, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Granulocyte differentiation activity versus TNFSF13B in UCEC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TNFSF13B →	+0.809	+0.170	<.001	<.001	3	6
GBM	PIK3CG →	+0.742	+0.224	<.001	.002	3	6
UCEC	CD48 →	+0.983	+0.193	<.001	.001	3	6
UCEC	GPR65 →	+0.729	+0.263	<.001	.001	3	6
UCEC	NCF1C →	+0.924	+0.248	<.001	.004	3	6
UCEC	SNX20 →	+0.844	+0.264	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030851 vs TNFSF13B — UCEC

Explore this scatter interactively →