Granulocyte differentiation

Across TCGA cell cohorts, RNA activity of the Granulocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEX3A, MTA1, and YLPM1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Granulocyte differentiation activity versus MEX3A in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MEX3A →	+0.603	+1.344	.002	.007	3	4
STOMACH	MTA1 →	+1.461	+0.304	<.001	.002	3	4
LUNG_SCLC	YLPM1 →	+0.613	+0.235	.006	.007	1	6
LUNG_SCLC	CTSA →	-1.432	-0.285	<.001	.003	3	4
BLOOD_Myeloma	NUMA1 →	+0.803	+0.217	.002	.001	3	4
LIVER	DRAM1 →	-1.365	-0.270	.007	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030851 vs MEX3A — UPPER_AERODIGESTIVE_TRACT

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