Prostate gland development

Across TCGA patient cohorts, RNA activity of the Prostate gland development pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OPTN_S177, PBK, and EIF2S2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prostate gland development activity versus OPTN_S177 in CCRCC (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	OPTN_S177 →	-1.022	-0.072	<.001	.001	3	6
OV	PBK →	-0.573	-0.036	.005	.007	3	6
OV	EIF2S2 →	-0.148	-0.026	.009	.006	3	6
HNSC	TRIM2_T371 →	+0.841	+0.070	<.001	<.001	3	5
BRCA	HELZ2 →	-0.419	-0.036	<.001	<.001	3	5
GBM	ADD3 →	+0.426	+0.044	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030850 vs OPTN_S177 — CCRCC

Explore this scatter interactively →