Prostate gland development

Across TCGA patient cohorts, RNA activity of the Prostate gland development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC14A2-AS1, CXCL12, and ITPKB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prostate gland development activity versus SLC14A2-AS1 in CCRCC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SLC14A2-AS1 →	+0.378	+0.205	.001	<.001	3	6
OV	CXCL12 →	+1.319	+0.218	.005	.002	3	5
PDAC	ITPKB →	+0.269	+0.170	.005	<.001	3	5
CCRCC	AEBP1 →	+1.530	+0.207	<.001	<.001	3	5
LSCC	LINC01415 →	+0.956	+0.149	.001	.001	3	5
BRCA	MGP →	+1.152	+0.103	.003	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030850 vs SLC14A2-AS1 — CCRCC

Explore this scatter interactively →