Prostate gland development

Across TCGA cell cohorts, RNA activity of the Prostate gland development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD99L2, TRIM68, and NME7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD99L2 grouped by Prostate gland development-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CD99L2 →	+0.988	+1.142	.003	<.001	3	3
OVARY	TRIM68 →	+0.608	+0.930	.003	.004	3	3
LUNG_SCLC	NME7 →	-0.850	-1.080	.003	.002	3	3
STOMACH	LRRC39 →	-0.700	-1.673	<.001	<.001	3	3
STOMACH	KMT2E →	-0.667	-1.119	.004	.006	3	3
SKIN	ANKRD20A1 →	-0.928	-1.006	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD99L2 by Prostate gland development activity — BLOOD_Leukemia

Explore this box plot interactively →