Prostate gland development

Across TCGA cell cohorts, RNA activity of the Prostate gland development pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRIP1, NDUFV3, and DENND1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prostate gland development activity versus CRIP1 in OESOPHAGUS (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CRIP1 →	+3.836	+0.612	<.001	.003	3	5
CNS	NDUFV3 →	-0.729	-1.018	<.001	.004	3	4
LUNG_SCLC	DENND1B →	-1.295	-0.374	<.001	.007	3	4
STOMACH	MAPK1 →	-1.036	-0.262	.007	.006	3	4
STOMACH	CCDC74A →	+1.740	+0.268	<.001	.004	3	4
KIDNEY	TFPI →	+2.644	+1.962	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030850 vs CRIP1 — OESOPHAGUS

Explore this scatter interactively →