Positive regulation of actin filament polymerization

Across TCGA patient cohorts, RNA activity of the Positive regulation of actin filament polymerization pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LMOD1_S85, RSU1, and SYNPO, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of actin filament polymerization activity versus LMOD1_S85 in UCEC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LMOD1_S85 →	+1.044	+0.065	<.001	<.001	3	10
OV	RSU1 →	+0.459	+0.056	<.001	<.001	3	10
PDAC	SYNPO →	+0.453	+0.043	<.001	<.001	3	10
CCRCC	SSC5D →	+0.716	+0.046	<.001	<.001	3	9
COAD	FERMT2 →	+0.617	+0.027	<.001	<.001	3	9
UCEC	PPP1R12B →	+0.708	+0.064	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030838 vs LMOD1_S85 — UCEC

Explore this scatter interactively →