Negative regulation of actin filament polymerization

Across TCGA cell cohorts, RNA activity of the Negative regulation of actin filament polymerization pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERGIC2, MISP, and MXRA8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ERGIC2 grouped by Negative regulation of actin filament polymerization-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ERGIC2 →	-0.713	-0.195	.004	.003	2	4
LUNG_NSCLC_LUSC	MISP →	+2.196	+0.228	.007	.003	3	3
KIDNEY	MXRA8 →	-2.455	-1.081	.001	.005	3	3
BLOOD_Leukemia	NPNT →	+0.244	+1.131	.008	.005	3	3
LUNG_SCLC	UBA2 →	-0.635	-0.683	<.001	.008	3	2
BREAST	ZMYND15 →	+0.628	+0.512	.003	.007	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ERGIC2 by Negative regulation of actin filament polymerization activity — LIVER

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