Positive regulation of actin filament depolymerization

Across TCGA patient cohorts, RNA activity of the Positive regulation of actin filament depolymerization pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CFL2, DNAJC7, and TNS1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of actin filament depolymerization activity versus CFL2 in HNSC (Pearson r = 0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CFL2 →	+0.804	+0.074	<.001	<.001	3	7
GBM	DNAJC7 →	-0.255	-0.080	<.001	<.001	3	7
COAD	TNS1 →	+0.433	+0.036	.004	.005	3	7
COAD	VCL →	+0.340	+0.026	<.001	.003	3	7
GBM	MAD2L1 →	-0.559	-0.089	<.001	<.001	3	7
HNSC	ANAPC7 →	-0.163	-0.100	<.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030836 vs CFL2 — HNSC

Explore this scatter interactively →