Positive regulation of actin filament depolymerization

Across TCGA cell cohorts, RNA activity of the Positive regulation of actin filament depolymerization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TWF2, SORBS2, and CERS4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TWF2 grouped by Positive regulation of actin filament depolymerization-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TWF2 →	+0.860	+1.180	<.001	.001	3	4
SOFT_TISSUE	SORBS2 →	+4.648	+1.474	.004	<.001	3	4
CNS	CERS4 →	+1.431	+0.818	.002	.001	3	4
PANCREAS	QRSL1 →	+0.513	+1.026	.003	.009	3	4
URINARY_TRACT	AP2A2 →	-1.039	-2.239	.006	<.001	3	4
LUNG_NSCLC_LUAD	MSI2 →	-0.858	-0.831	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TWF2 by Positive regulation of actin filament depolymerization activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →