Negative regulation of actin filament depolymerization

Across TCGA patient cohorts, RNA activity of the Negative regulation of actin filament depolymerization pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MGP, FHL5, and KIF18A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of actin filament depolymerization activity versus MGP in LUAD (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MGP →	+1.025	+0.227	<.001	.001	3	6
UCEC	FHL5 →	+1.085	+0.304	<.001	.001	3	6
UCEC	KIF18A →	-0.954	-0.357	<.001	<.001	3	6
LUAD	C1QTNF2 →	+0.658	+0.213	<.001	.001	3	6
LUAD	NCAPG2 →	-0.695	-0.209	<.001	.002	3	6
BRCA	CAVIN2 →	+1.250	+0.253	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030835 vs MGP — LUAD

Explore this scatter interactively →